The role of clinical parameters and cathepsin S gene expression in predicting the development of postoperative pain in patients with hip osteoarthritis

Objective : to evaluate the significance of clinical indicators, expression pain syndrome genes cathepsin S and pro-inflammatory cytokines in peripheral blood for predicting development postoperative (POP) patients with hip osteoarthritis (HOA) before total arthroplasty (TA). Material methods. The study included 31 stages III–IV HOA (mean age 61.3±9.8 years) who underwent TA 26 healthy volunteers (control group). Depending on presence or absence POP, were divided into two subgroups: POP (1st subgroup, n=12) without (2nd n=19). Patients examined 6 months after surgery. Prior TA, level was determined all using visual analogue scale (VAS), as well DN4 PainDETECT neuropathic questionnaires. Functional status assessed by WOMAC index. ≥ 30 mm according VAS TA. Total RNA isolated from whole used gene S, interleukin 1 (IL1 ), tumor necrosis factor α (TNF cyclooxygenase 2 (COX2) quantitative real-time polymerase chain reaction. Results discussion . Complaints persisted 12 (38.7%) Before surgery, IL1 , TNF COX2 significantly higher both subgroups compared controls. In addition, not satisfied outcome rates questionnaire than other patients. At same time, there no significant difference studied Conclusion may be partially associated its perception mechanisms disturbance, an increase prior can serve prognostic biomarker.